Fig. 5
From: SOX9 is a key component of RUNX2-regulated transcriptional circuitry in osteosarcoma
Proximitome analyses reveal RUNX2 and JMJD1C as novel binding partners of SOX9. A, Schematic showing BioID2 to identify the proximitome of SOX9 in DUNN cells. B, The network of SOX9 proximitome by STRING. C, Proximity ligation assay (PLA) showing the interaction between SOX9 and RUNX2. D, Co-immunoprecipitation of SOX9 and RUNX2 in SAOS2 cells. E, Venn diagram showing SOX9-interacting proteins that play a conservative role in mouse osteosarcomagenesis. OS-associated genes were from a public dataset [22]. F, PLA showing the interaction between SOX9 and JMJD1C. G, Analyses of public microarray datasets showing overexpression of JMJD1C in OS versus normal tissues