Fig. 4
From: SOX9 is a key component of RUNX2-regulated transcriptional circuitry in osteosarcoma
SOX9 regulates MYC expression. A, Venn diagram of SOX9-regulated transcripts by two shRNAs. B, Ingenuity Pathway Analysis (IPA) showing enriched pathways in SOX9-regulated transcripts (common between the two shRNAs). Left, pathways downregulated in shSOX9 (activated by SOX9); Right, pathways upregulated in shSOX9 (repressed by SOX9). C, Heatmap showing SOX9-activated and SOX9-repressed transcripts and highlighting MYC as a SOX9-activated gene. D, Gene Set Enrichment Analysis (GSEA) showing MYC gene signature is enriched in SOX9-regulated transcripts