Fig. 3
From: SOX9 is a key component of RUNX2-regulated transcriptional circuitry in osteosarcoma
SOX9 is a survival factor of OS in vivo. A, Images of xenografts from SAOS2_shLuc (control), SAOS2_shSOX9_3 and SAOS2_shSOX9_5 taken at 63 days after cell injection. B, Tumor weights of xenografts from SAOS2 cells with different genotypes as indicated. n = 10 for shLuc; 9 for shSOX9_3 (one out of 10 mice had no tumor), and 8 for shSOX9_5 (two out of 10 mice had no tumor). p-values are from the Mann–Whitney test. C, Kaplan–Meier survival curve showing the overall survival of mice bearing subcutaneous tumors. Ten mice for each group. p-values are from the log-rank (Mantel-Cox) test. D, Representative images of immunohistochemistry (IHC) showing Ki-67 and cleaved caspase 3 staining. E and F, Quantitative analyses of Ki-67 (E) and cleave caspase 3 (F)