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Fig. 6 | Cell & Bioscience

Fig. 6

From: Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer

Fig. 6

Molecular mechanism of tumor suppression by copper chelator therapy. TEPA has a regulatory effect on tumor invasion and metastasis by attenuating the canonical TGF-β/pSMAD2&3 and non-canonical TGF-β/AKT/mTOR, TGF-β/RAS/RAF/MEK/ERK, and TGF-β/WNT/β-catenin signaling pathways and downstream target genes related to EMT process in cancer initiation and progression. Blue and red arrows indicate downregulation and upregulation, respectively

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Cell & Bioscience

ISSN: 2045-3701

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