Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2

Cell & Bioscience

Table 1 Regulations of TMPRSS2 and 3CLpro by the phytochemicals in Artemisia argyi in FRET-based enzymatic activity assays

Compounds	Molecular formula	Suppression level of TMPRSS2 activity^a	p-value^b	Suppression level of 3CL^pro activity^a	p-value^c
13-Oxo-9E, 11E-octadecadienoic acid	C₁₈H₃₀O₃	76.0% ± 4.7%	< 0.001	39.5% ± 4.7%	< 0.001
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone	C₁₈H₁₆O₈	12.5% ± 9.1%	0.127	6.0% ± 4.1%	0.108
beta-Rhamnocitrin	C₁₆H₁₂O₇	43.8% ± 22.8%	0.053	− 4.3% ± 3.2%	0.145
Dammaradienyl acetate	C₃₂H₅₂O₂	− 9.7% ± 2.0%	0.005	− 4.5% ± 10.3%	0.572
Daphnetin	C₉H₆O₄	37.8% ± 10.1%	0.006	7.9% ± 0.7%	< 0.001
Daucosterol	C₃₅H₆₀O₆	9.4% ± 3.7%	0.027	2.1% ± 0.3%	0.033
Eriodictyol	C₁₅H₁₂O₆	100.0% ± 0.3%	< 0.001	− 1.7% ± 0.4%	0.073
Eupatilin	C₁₈H₁₆O₇	-1.3% ± 0.3%	0.267	5.1% ± 5.1%	0.236
Hispidulin	C₁₆H₁₂O₆	13.0% ± 0.7%	< 0.001	-2.5% ± 0.1%	0.018
Jaceosidin	C₁₇H₁₄O₇	51.8% ± 5.2%	< 0.001	11.6% ± 3.6%	0.012
Linarin	C₂₈H₃₂O₁₄	-6.6% ± 1.2%	0.007	1.6% ± 0.4%	0.076
Octacosanoic acid	C₂₈H₅₆O₂	− 43.3% ± 40.2%	0.203	− 1.0% ± 4.2%	0.775
Stigmasterol	C₂₉H₄₈O	8.4% ± 7.6%	0.197	3.6% ± 3.8%	0.255
Umbelliferone	C₉H₆O₃	74.1% ± 3.5%	< 0.001	− 4.0% ± 0.9%	0.012