Table 1 m6A methylation related enzymes in HF

CCL4-induced mouse and M1-polarized macrophages

METTL3

Up-regulated

Stimulating pyroptosis and inflammation of macrophages, aggravates liver fibrosis

MALAT1/PTBP1/ USP8/TAK1

[100]

The activated HSC

METTL3

Up-regulated

Promotes the expression of fibrosis related genes

Lats2

[101]

PDGF-BB-induced activated HSC-T6

METTL3

Up-regulated

Promotes HSC activation

ASIC1a

[102]

High-fat diet induced rats

METTL3/14

Up-regulated

Promote the transition of NASH to HF

TGF-β1

[103]

Chronic corticosterone stimulation of chicken liver

METTL3

Up-regulated

Induces fibrosis in chicken

Heat shock proteins

[104]

A model of NAFLD in mice with type 2 diabetes mellitus

METTL3/14

Up-regulated

Promote NAFLD conversion to fibrosis

ACLY and SCD1

[105]

CCL4-induced rat and TGF-β1 treated HSC

WTAP

Up-regulated

Promotes HSC activation

Ptch1

[106]

Tissue of patients with mild and severe fibrosis

METTL16

Up-regulated

Regulating the m6A level and expression of HLA-DPB1

HLA-DPB1

[107]

Tissues of patients with liver cirrhosis complicated with HCC treated with sorafenib and CCL4-induced mouse

YTHDF1

Down-regulated

Triggers autophagy activation, and enhances HSC ferroptosis

BECN1

[108]

Mice were induced by a mixture of CCL4 and olive oil (1:9)

FTO

Up-regulated

Triggers autophagy activation, and enhances HSC ferroptosis

BECN1

[109]

TGF-β1 treated HSC

ALKBH5

Down-regulated

Improved liver fibrosis and inhibited HSC activation

PTCH1

[110]

Chronically HBV infected cases

ALKBH5

Up-regulated

ALKBH5 interacting with macrophage and WTAP interacting with nature killer T cells to promote hepatic fibrosis

Macrophage and killer T cells

[111]

WTAP

Liver tissue from patients with chronic fibrosis and CCL4-induced mouse

YTHDF3

Down-regulated

Promotes HSC activation

PRDX3

[112]