Fig. 1
From: RNA methylations in hepatic fibrosis, a gradually emerging new treatment strategy
Mechanisms of hepatic fibrosis. Chronic liver injury mediated by different risk factors activates several parenchymal and non-parenchymal cells and promotes hepatic inflammation by producing many inflammatory mediators. Extreme inflammation drives the activation of hepatic stellate cells, which are then transformed into the proliferative and extracellular matrix, giving rise to myofibroblasts, leading to fibrosis and liver dysfunction. NAFLD non-alcoholic fatty liver disease, NASH nonalcoholic steatohepatitis, KCs kupffer cells, TGF-β transforming growth factor beta, TNF-α tumor necrosis factor-alpha, TIM-4 T-cell immunoglobulin and mucin-4, IRF-5 interferon regulatory factor-5, NLRP3 NLR family pyrin structural domain containing 3, HSCs hepatic stellate cells