Fig. 7
From: ER Ca2+ overload activates the IRE1α signaling and promotes cell survival
Graphical Abstract for TMCO1 deficiency-induced the activation of IRE1α-XBP1s axis. Graphical Abstract: under basal conditions, the monomeric inactive state of IRE1α is maintained through the interaction with chaperone BiP. In the case of TMCO1 knockdown, the induced overfilling of Ca2+ signaling decreases the interaction between IRE1α and BiP, increases IRE1α dimerization and then promotes cell survival through sensitizing IRE1α-XBP1 axis