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Fig. 7 | Cell & Bioscience

Fig. 7

From: Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Fig. 7

PRSS56 promotes GC and CRC via activation of PI3K/AKT axis. (A, B) The differences in transcriptome between GC patients with PRSS56 overexpression and GC patients without PRSS56 expression. (C) The genes upregulated in GC patients with PRSS56 overexpression were used to conducted KEGG pathway analysis. (D) The genes downregulated in GC patients with PRSS56 overexpression were used for conducting KEGG pathway analysis. (E) Western blotting assay confirmed that PRSS56 overexpression activated the PI3K/AKT axis. (F, G) Rescue colony formation assay using PI3K inhibitor (LY294002, 10 µM) confirmed that PRSS56 overexpression promoted GC and CRC cells proliferation through PI3K/AKT axis. **, P < 0.01

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Cell & Bioscience

ISSN: 2045-3701

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