Fig. 4

The correlation analysis between PRSS56 expression and DNA methylation level in GC and CRC. (A) The UCSC web tool showed that there is a CpG island in the PRSS56 gene body DNA. (B) The CpG sites in PRSS56 promoter and gene body DNA were displayed using the MEEXPRESS web tool. (C) The methylation level of PRSS56 promoter DNA is significantly higher than that of gene body DNA. The methylation data of each CpG site was obtained from TCGA_STAD samples. (D, E) PRSS56 expression was positively correlated with promoter DNA methylation and negatively correlated with gene body DNA methylation in GC and CRC. The methylation data of each CpG site and PRSS56 expression data were obtained from TCGA database. (F-I) PRSS56 expression was negatively correlated with the methylation level of the CpG sites in GC and CRC