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Fig. 2 | Cell & Bioscience

Fig. 2

From: Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Fig. 2

Serine protease PRSS56 was frequently overexpressed in cancers. (A) Single-cell analysis revealed that there were nine cell types in the normal testis tissue. The single-cell plot here was screenshots from the HPA database. (B) Serine proteases that can be detected expression data by single cell RNA sequencing were shown in the plot. The single-cell heat plots of different serine proteases were screenshots from the HPA database. (C) The testis-specific serine proteases were significantly downregulated in testis cancer. (D, E) Most of the testis-specific serine protease genes were significantly upregulated in GC and CRC. (F) The expression pattern of testis-specific serine protease PRSS56 was analyzed in pan-cancer. (G) The frequency of PRSS56 overexpression in pan-cancer was analyzed. The expression data (TPM value) of PRSS56 greater than 0.1 was considered overexpressed

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Cell & Bioscience

ISSN: 2045-3701

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