Fig. 2

TRIM67 upregulation reduces the infarct volume and improves neurological function in mice after cerebral ischemia‒reperfusion injury. A Schematic of CMV-dependent adeno-associated virus for vectors or wild-type TRIM67 overexpression. B Cerebral blood flow monitored using 2-dimensional laser speckle imaging techniques before, during MCAO, and reperfusion. C The results are expressed as the percent change from baseline (pre-MCAO). D Diagram showing the experimental process. E After 24 h of MCAO, representative brain slices were stained with TTC. F Infarct volume quantitative analysis (n = 8). (G) The modified neurological severity score (mNSS) was used to determine the neurological deficiency score (n = 8). The mean ± SD are displayed for all data. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001