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Fig. 7 | Cell & Bioscience

Fig. 7

From: SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair

Fig. 7

Schematic diagram of SETD8 inhibition sensitizes cervical cancer cells to cisplatin treatment. Downregulation of SETD8 significantly reduces the mono-methylation level of H4K20 (H4K20me1) and double-methylation level of H4K20 (H4K20me2) in cervical cancer and further reduces the recruitment of the DNA damage repair factor 53BP1, inhibits the non-homologous end joining repair pathway (NHEJ), resulting in increased cisplatin-induced DNA damage

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Cell & Bioscience

ISSN: 2045-3701

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