Fig. 9

Enhanced inhibitory effects of M/Ts in OB of 6-month-old SNCA-A53T mice after administration of TGB. a-b Representative images (a) and input-output curves (b) of PG-M IPSCs of M/Ts in OB of WT and A53T mice treated with saline or TGB (n = 4 for each group). c Quantitative analysis of the slope of (b) in WT and A53T mice treated with saline or TGB (n = 4 for each group). d-e Representative images (d) and input-output curves (e) of GC-M IPSCs of M/Ts in OB of WT and A53T mice treated with saline or TGB (n = 4 for each group). f Quantitative analysis of the slope of (e) in WT and A53T mice treated with saline or TGB (n = 4 for each group). g Representative images showing mIPSCs of M/Ts in OB. h-i Cumulative curves (h) and quantification (i) of mIPSCs frequency of M/Ts in OB of WT and A53T mice treated with saline or TGB (n = 4 for each group). j-k Cumulative curves (j) and quantification (k) of mIPSCs amplitude of M/Ts in OB of WT and A53T mice treated with saline or TGB (n = 4 for each group). l-m Representative images (l) and quantification (m) of normalized sAP frequency of M/Ts in OB of WT and A53T mice treated with saline or TGB (n = 4 for each group). Data are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; n.s., not significant