Fig. 6

Altered adult neurogenesis in OB of 6-month-old SNCA-A53T mice. a Representative images showing BrdU and NeuN co-immunostaining of OB. b-c Quantitative analysis of BrdU-positive (b) and BrdU/NeuN double-positive (c) neurons in OB of WT and A53T mice (n = 3 for each group). d Schematic diagram illustrating labeling the adult-born neurons of OB by injection of the AAV1-CMV-EGFP into RMS. e Representative images showing the spines of adult-born neurons in OB. f Quantitative analysis of the spine density of adult-born neurons in OB of WT and A53T mice (n = 3 for each group). g-n Representative images and quantification of the TH-positive (g, h), CalB-positive (i, j), CalR-positive (k, l), and PV-positive (m, n) neurons in OB of WT and A53T mice (n = 3 for each group). Data are presented as mean ± SEM. *p < 0.05; n.s., not significant