Fig. 4

The excitation/inhibition imbalance in OB of 6-month-old SNCA-A53T mice. a Schematic diagram illustrating the fEPSP recording in OB. b Representative images showing mixed (indicated as black and red traces) and pure (indicated as blue and purple traces) fEPSP in OB of WT and A53T mice. c Input-output curves of mixed and pure fEPSP in OB of WT and A53T mice (n = 4 for each group). d-f Quantitative analysis of averaged pure fEPSP area (d), averaged area of fIPSP (e) and the ratio of E/I (f) in OB of WT and A53T mice under the last three stimuli (n = 4 for each group). g-h Representative images (g) and input-output curves (h) of OE-M EPSCs of M/Ts in OB of WT and A53T mice (n = 4 for each group). i Quantitative analysis of the slope of (h) in WT and A53T mice (n = 4 for each group). j-k Representative images (j) and input-output curves (k) of PG-M IPSCs of M/Ts in OB of WT and A53T mice (n = 4 for each group). l Quantitative analysis of the slope of (k) in WT and A53T mice (n = 4 for each group). m-n Representative images (m) and input-output curves (n) of GC-M IPSCs of M/Ts in OB of WT and A53T mice (n = 4 for each group). o Quantitative analysis of the slope of (n) in WT and A53T mice (n = 4 for each group). Data are presented as mean ± SEM. *p < 0.05; **p < 0.01; n.s., not significant