Fig. 10

Schematic illustration of the local neural microcircuit mechanisms underlying olfactory dysfunction in SNCA-A53T mice. At 6 months of age, SNCA-A53T mice exhibited unchanged OSNs and glutamatergic innervation from OE to OB, but displayed impaired GABAergic inhibition of M/Ts from multiple interneurons in different layers of OB, which was attributed to the aberrant GAT1 and VGAT levels and GABAergic transmission. Together, these alterations led to the hyperactivity of M/Ts, the E/I imbalance in OB and subsequent olfactory dysfunction