Fig. 2
From: Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation
Different effects on intestinal immunity between persistent activation and defective AHR activation. a. persistent activation by AHR ligands has deleterious consequences. b. defective AHR activation is detrimental to the maintenance of intestinal homeostasis. This balance of intestinal homeostasis requires appropriate level of AHR activation. I3C, indole-3-carbinol; IEL, intraepithelial lymphocytes; ILC3, intraepithelial lymphocytes and type 3 innate lymphoid cells