Fig. 8

Novel interactions between injured-proximal tubular and immune cells. A Schematic of ligand–receptor interaction in injured-PT subpopulations at the leading edge and in immune cells. B and C Bar plots of significant ligand–receptor (L-R) pairs (P < 0.05) when PTs expressed ligands and immune cells expressed receptors matched to the cell types in snRNA-seq data. D Left: heatmap of snRNA-seq average log fold change (logFC) of NicheNet top predicted ligands expressed by injured-PT cells that modulated immune cell types. Middle: heatmap of significant L-R pairs between injured-PT subpopulations and immune cell types in snRNA-seq. Bottom: heatmap of snRNA-seq average logFC of ligand-matched receptors expressed by immune cell types. E and F Bar plots of significant L-R pairs (P < 0.05) when monocytes and macrophages and granulocytes expressed ligands and injured-PTs expressed receptors matched to cell types in snRNA-seq data. G Left: heatmap of snRNA-seq average log fold change (logFC) of NicheNet top predicted ligands expressed by monocyte and macrophages and granulocytes that modulated injured-PT cells. Middle: heatmap of significant ligand–receptor pairs between immune cell types and injured-PT subpopulations pair in snRNA-seq. Bottom: heatmap of snRNA-seq average logFC of ligand-matched receptors expressed by injured-PT subpopulations