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Fig. 1 | Cell & Bioscience

Fig. 1

From: Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi rats

Fig. 1

A single-cell transcriptomic analysis of rats with calculi. A Study design and workflow of rat kidney sample processing for snRNA-seq and spatial architecture analysis. B Histochemical validation and von Kossa staining of the calcium crystals in the urolithiasis model via HE staining; the green arrows indicate the crystals. Original magnification, 10 × 40. C Uniform manifold approximation and projection (UMAP) of snRNA-seq cells recovered from the kidneys of both normal rats and rats with calculi, as well as proximal tubular and BI subsets

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