Fig. 1

Aging phenotype of Tagln^−/− mice is alleviated compared with that of WT mice. (a) Representative images of the skin in WT mice (left) and Tagln^−/− mice (right) obtained by Antera 3D. (b) Wrinkle score and maximum depth measured by Antera 3D. (c and d) H&E staining showing the dermis thickness of Tagln^−/− mice skin and Masson staining showing the accumulation of collagen (blue). Scale bar: 100 μm. e and f) IHC analyses of MMP1 and COL1A2 in the skin of WT and Tagln^−/− mice. Representative images (e) and staining scores (f) are shown. Scale bar: 100 μm. (g and i) Levels of Hyp (g), MDA (h), and SOD (i) in WT and Tagln^−/− mice. All values are expressed as mean ± SD, n.s, not significant, ^*P < 0.05, ^**P < 0.01