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Fig. 2 | Cell & Bioscience

Fig. 2

From: The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway

Fig. 2

BCL6 attenuates malignant phenotypes in AGS and SGC-7901 cells. A Expression levels of BCL6 in AGS and SGC-7901 cells infected with BCL6 overexpression virus and empty virus were analyzed by western blotting assay (***p < 0.001). B, C BCL6 inhibits the viability and proliferation of AGS and SGC-7901 cells (***p < 0.001). D BCL6 inhibited the migration of AGS and SGC-7901 cells (***p < 0.001). E BCL6 inhibited the migration and invasion of AGS and SGC-7901 cells (***p < 0.001). F BCL6 inhibited the EMT process of AGS and SGC-7901 cells. G BCL6 inhibited the growth of SGC-7901 cells in vivo. Tumor growth curves and tumor weight shows the inhibitory effect of BCL6 on tumor in vivo (N = 6) (*p < 0.05, ***p < 0.001). H Representative hematoxylin and eosin (HE) staining and immunohistochemical (IHC) images of tumor xenografts derived from SGC-7901-NC, SGC-7901-BCL6 cell lines stained by BCL6 antibody (Original magnification, × 400). I BCL6 inhibited the intraperitoneal metastasis of SGC-7901 cells in vivo. Number and weight of disseminated tumour foci shows the metastasis inhibitory effect of BCL6 on tumor in vivo (**p < 0.01). J Representative HE and IHC staining of metastatic foci derived from SGC-7901-NC, SGC-7901-BCL6 cell lines (Original magnification, × 400)

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Cell & Bioscience

ISSN: 2045-3701

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