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Fig. 3 | Cell & Bioscience

Fig. 3

From: Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα

Fig. 3

Exos treatment promotes M2 polarization of microglia/macrophages in vivo. a Detection of mRNA levels of M1 and M2 markers in injured spinal cords at day 7 post-injury.**P = 0.0016, ***P < 0.001. b, c Detection and quantification of iNOS and Arg1 protein expression level at day 7 post-injury. **P = 0.0058, ***P = 0.0005. d, e Double-staining of CD68 and iNOS at day 7 after SCI and quantification of CD68+ cells and M1 microglia/macrophages (Scale bar = 100 μm). ***P = 0.0003. f, g Double-staining of CD68 and Arg1 at day 7 after SCI and quantification of CD68+ cells and M2 microglia/macrophages (Scale bar = 100 μm). ***P = 0.0007

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Cell & Bioscience

ISSN: 2045-3701

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