Fig. 5

In vivo visualization of LPS-induced inflammation in living mice using N-TIP. A Schematic procedures for in vivo study. For inflammation induction, LPS solution was injected into the paw of mice, immediately followed by a 0.4 mg/kg N-TIP injection. In vivo fluorescence imaging was conducted at indicated times. B In vivo detection of LPS-induced inflammatory lesion using N-TIP. C, D Quantification of FL signals in (B) panel. E Measurement of paw thickness after PBS or LPS injection. Data are the mean ± SD of 5 mice. *p < 0.05, **p < 0.01, ***p < 0.0005, n.s., not significant