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Fig. 6 | Cell & Bioscience

Fig. 6

From: GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint

Fig. 6

Downregulation of GPR116 enhances antitumor activity of NKG2D-CAR-NK92 cells against xenografts formed by PANC28 in mice. A, B Tumor bioluminescence images of mice transplanted with PANC28/luc cells at the indicated time points. C, D Line plots displaying the tumor weight and the body weight of mice. E The proportion of NK92 cells in tumors was measured by flow cytometry. F The expression of GzmB in tumor-infiltrating NKG2D-CAR-NK92 cells. G The expression of IFNγ in tumor-infiltrating NKG2D-CAR-NK92 cells. Data are represented as the mean ± standard error of the mean (SEM). ns no significance, *P < 0.05, **P < 0.01 by an unpaired Student’s t-test

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Cell & Bioscience

ISSN: 2045-3701

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