Fig. 6

Role of l-arginine (LA) mediated ROS/NLRP3/NF-κB signaling pathway in COPD mice. Western blot of ROS/NLRP3/NF-κB signaling pathway in lung in COPD KO mice (A), Quantification of ROS/NLRP3/NF-κB signaling pathway in Ass-1 KO COPD mice (B). The expression levels of NLRP3 and p-NF-κBp65 in lung tissue in Ass-1 KO COPD mice by immunohistochemistry (× 200) (C). Quantification of NLRP3 and p-NF-κBp65 (D) of lung tissue in KO COPD mice. (n = 3). All data were presented as mean ± SD. Compared with WT mice: ^##P < 0.01