Fig. 3

Effects of l-arginine (LA) on KO COPD mice. Airway reaction (A). The percentage changes of the resistance of lung (RL) (B) and lung dynamic compliance (Cdyn) (C) in WT and KO COPD mice. Serum cytokines: The contents of interleukin-1β (IL-1β) (D), interleukin-6 (IL-6) (E), tumor necrosis factor-α (TNF-α) (F). BALF cytokines: the contents of Interleukin-1β (IL-1β) (G), interleukin-6 (IL-6) (H), tumor necrosis factor-α (TNF-α) (I). Reactive oxygen species (ROS) (J) and nitric oxide (NO) (K) contents in lung tissues. Pathological changes (HE staining) and Masson staining of lung in COPD rats: HE staining of lung in COPD rats (× 200) (L), Masson staining of lung in COPD rats (× 200) (M), Collagen quantification of Masson staining and collagen I contents of lung in COPD KO mice (N). (n = 10). All data were presented as mean ± SD. Compared with WT mice: ^##P < 0.01