Fig. 7

YAP1 overexpression reversed tumor suppression caused by TPM2 overexpression. A–E The YAP1 overexpression plasmid was co-transfected with TPM2 overexpression plasmid to see if it could reverse the tumor suppression caused by TPM2. The proliferation capacities of the PCa cells were detected by CCK-8, colony formation, and EdU assays. Transwell assays were used to assess the migration and invasion ability of cells. A–C Cell proliferation assays: CCK-8 and EdU assays. D, E Transwell migration and invasion assays. F Model of TPM2 attenuates prostate cancer progression by blocking PDLIM7-mediated nuclear translocation of YAP1. PBM PDZ binding motif, ns no significance, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001