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Fig. 2 | Cell & Bioscience

Fig. 2

From: TPM2 attenuates progression of prostate cancer by blocking PDLIM7-mediated nuclear translocation of YAP1

Fig. 2

TPM2 attenuates proliferation and invasion of PCa cells. A–G TPM2 was overexpressed to explore its function in C4-2B and PC-3 cells. The proliferation capacities of the PCa cells were detected by CCK-8, colony formation, and EdU assays. Transwell assays were used to assess the migration and invasion ability of cells: A protein expression levels of TPM2 in C4-2B and PC-3 cells following TPM2 overexpression. B–E Cell proliferation assays: CCK-8, colony formation, and EdU assays. F, G Transwell migration and invasion assays. H–L The malignant phenotypes of LNcap cells transfected with TPM2 siRNA interference: H protein expression levels of TPM2 in LNCaP cell following TPM2 siRNA interference. I, J Cell proliferation assays: CCK-8 and EdU assays. K, L Transwell migration and invasion assays. The data were presented as mean ± SD. **P < 0.01, ***P < 0.001, ****P < 0.0001

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Cell & Bioscience

ISSN: 2045-3701

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