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Fig. 7 | Cell & Bioscience

Fig. 7

From: RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex

Fig. 7

RBX1 promotes ATC migration and aerobic glycolysis via SMAR1. A Western blotting was performed to determine the SMAR1 and RBX1 expression in various groups. B, C Quantification of transwell assay in various groups. *P < 0.05, **P < 0.01. D, E Quantification of EdU assays in different groups. *P < 0.05, **P < 0.01. F Cellular glucose consumption, G6P levels, ATP levels, and lactate generation in specific groups. *P < 0.05, **P < 0.01. G, H Measurement of OCR and ECAR in specific groups. *P < 0.05. I SMAR1 and RBX1 expression levels in various groups were determined using western blotting. J, K Quantification of transwell assays in different groups. *P < 0.05, **P < 0.01. L, M Quantification of EdU assays in different groups. *P < 0.05, **P < 0.01. N Cellular glucose consumption, G6P levels, ATP levels, and lactate generation in specific groups. *P < 0.05, **P < 0.01. O, P ECAR and OCR were measured in the indicated groups. *P < 0.05, **P < 0.01

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