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Fig. 3 | Cell & Bioscience

Fig. 3

From: RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex

Fig. 3

RBX1 promotes ATC progression by enhancing the Warburg effect. A Cellular glucose consumption, G6P levels, ATP levels, and lactate generation in CAL62/shRBX1 cells. *P < 0.05. B Cellular glucose consumption, G6P levels, ATP levels, and lactate generation in 8305C/HA-RBX1 cells. *P < 0.05. C, D ECAR data showing the glycolytic rate and capacity in CAL62/shRBX1 cells. E, F ECAR data showing the glycolytic rate and capacity in 8305C/HA-RBX1 cells. G, H OCR results showing basal respiration and maximum respiration in CAL62/shRBX1 cells. I, J OCR results showing basal respiration and maximum respiration in 8305C/HA-RBX1 cells. K, L Lactate generation by 8305C/p-RBCK1 or CAL62/shRBX1 cells in the presence of 2-DG. *P < 0.05, **P < 0.01. M, N Role of 2-DG in the invasion and migration of 8305C/p-RBCK1 or CAL62/shRBX1 cells. *P < 0.05, **P < 0.01. O–Q Culturing 8305C cells in a medium with galactose but without glucose abolished the impact of RBX1 overexpression on cell invasion and migration, NS = No Significant

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Cell & Bioscience

ISSN: 2045-3701

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