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Fig. 8 | Cell & Bioscience

Fig. 8

From: ARPC1A correlates with poor prognosis in prostate cancer and is up-regulated by glutamine metabolism to promote tumor cell migration, invasion and cytoskeletal changes

Fig. 8

Glutamine metabolism promotes migration, invasion, and cytoskeleton morphology by up-regulating ARPC1A expression in PCa cells. A GSEA analysis revealed a significant positive association between high ARPC1A expression and glutamine metabolism. B Proposed model describing the roles of glutamine metabolism and ARPC1A in PCa. C–E ARPC1A expression, cytoskeletal morphology, and the migration and invasion potential of PC-3 cells cultured in different types of media. *: P < 0.05; ns no statistical significance, Gln glutamine, Glc Glucose, DKG dimethyl α-ketoglutarate. F–H ARPC1A expression, cytoskeletal morphology, and the migration and invasion potential of PC-3 cells under the indicated treatment conditions. *: P < 0.05; ns no statistical significance

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Cell & Bioscience

ISSN: 2045-3701

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