Fig. 7

Overexpression of ARPC1A promotes lung metastasis of PCa, but has no effect on tumor growth. A–C WB and qRT-PCR were performed to verify ARPC1A overexpression in the ARPC1A stable PC-3 cell line. *: P < 0.05. D–F Subcutaneous xenograft tumor experiment was performed to evaluate the effect of ARPC1A on tumor growth, E the size and F the weight of xenograft tumors was measured. ns: no statistical significance. G–J Lung metastasis model was established to evaluate the effect of ARPC1A on tumor metastasis, H the fluorescent signal of lung metastases was detected and I the number of metastatic nodules was counted; J Representative HE staining of lung tissues. Arrowheads indicate the metastatic nodules. *: P < 0.05