Fig. 5

Knockdown of ARPC1A inhibits PCa cell migration and invasion in vitro. A–C The GSEA gene sets that have the strongest association with high ARPC1A expression in PCa cells. D–G WB and qRT-PCR analysis was performed on PC-3 and DU-145 cells to validate the silencing efficiency of siRNAs. *: P < 0.05, compared with control group; #: P < 0.05, compared with the siRNA NC group. (H–K) Differences in migration between control and ARPC1A siRNA-transfected PCa cells, as determined using a wound healing assay. *: P < 0.05. L–O Differences in migration and invasion between control and ARPC1A siRNA-transfected PCa cells as determined using Transwell assays. *: P < 0.05