Fig.5

Computer model of CA1 neuronal firing pattern. A A schematic model of a CA1 pyramidal neuron. B APs evoked by rheobase in the cell model containing normal (0.02) or the half (0.01) of K_v1.1. C The same strength of stimulation induces a single AP with K_v1.1 (0.02), but doublet APs with insufficient K_v1.1 (0.01). D A reduction in K_v1.1 results in more firing when the cell receives a 200-pA current injection (400 ms) (gray bars, intervals between 1st and 2nd spikes). E Reduced K_v1.1 results in less firing when the cell receives a 700-pA current injection (400 ms). F The amplifications of 1^st and 4^th spikes induced by 200-pA current. Note the difference in the half-width between 1^st and 4^th spikes, or between normal and half K_v1.1 conditions. G The amplifications of 1^st and 5^th AHPs and fitting analysis (gray lines) of AHP currents with normal or half K_v1.1