Fig. 2

Glycomic overview of various AML cell lines. a PCA of glycosylation features derived from glycomics data of 19 AML cell lines. Individual cell lines are annotated and colored by their FAB classifications as assigned earlier [13]. b The associated score plot depicts considered glycan features, which are linked to their respective glycan class (N-, O-, and GSL) by color (purple, orange, and green) and symbol (triangle, square, and circle). In addition, arrows indicate features that are linked to a specific type of fucosylation. c Radar plots are showing the differences in glycosylation features between AML classes M5 and M6. Again, these features are subdivided into their respective classes based on color and symbols. Data on all AML cell lines were z-transformed prior to visualizing differences between FAB classes in these radar plots. d Spearman correlation of selected glycosylation features between the different glycan classes. Thick connective lines indicate a good correlation whereas thin connective lines show less correlation. Correlation values are depicted