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Fig. 3 | Cell & Bioscience

Fig. 3

From: GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

Fig. 3

GLIS3, NKX2.1, and PAX8 share binding loci within the regulatory regions of several TH biosynthetic genes. A Colocalization of GLIS3, NKX2.1, and/or PAX8 ChIP-seq loci in genes critical for TH biosynthesis. The NUE region in Slc5a5 (Nis) is indicated. B, C NKX2.1 and PAX8 analysis at Cdh16 (− 0.2 kb), Slc5a5 (− 2.8 kb), and Tpo (− 0.1 kb) with thyroid glands from WT and Glis3KO mice. Binding to Gapdh and Tpo (− 1.9 kb) served as negative controls

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Cell & Bioscience

ISSN: 2045-3701

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