Fig. 2

GLIS3, NKX2.1 and PAX8 binding to the mouse thyroid gland genome partially overlap. A The number of collapsed binding regions that are positive for GLIS3, NKX2.1, and PAX8 signal, and the percent overlap between them are indicated. B Heatmap showing overlap between GLIS3, NKX2.1, and PAX8 binding. Heatmap of the 2 kb region centered on each of the binding regions with ChIP-seq signal normalized to 10 million reads. C Venn diagram showing the number of target genes with GLIS3, NKX2.1, and/or PAX8 binding regions. D Venn diagram showing the overlap of G⁺N⁺P⁺ genes with genes up- or down-regulated in the thyroid gland of Glis3KO-LID mice compared to that of WT-LID mice. E KEGG analysis of the 4502 G⁺N⁺P⁺ genes