Fig. 4From: Metabolic reprogramming in colorectal cancer: regulatory networks and therapySimplified Schematic of the De Novo Pyrimidine and Purine Synthesis Pathways in CRC Cells. Phosphoribose-1-pyrophosphate (PRPP) derived from the PPP pathway participates in the synthesis of pyrimidine and purine via distinct pathways with different substrates. Brown boxes indicate metabolic enzymes. Blue boxes represent factors that alter nucleotide metabolismBack to article page