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Fig. 6 | Cell & Bioscience

Fig. 6

From: HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA

Fig. 6

Pseudoknot stems P1 and P2 are conserved between HIV-1 and SIVcpz. A Alignment of the region upstream of 3’-TAR in the HIV-1 LAI strain (Genbank reference K03455) with simian immunodeficiency virus strains SIVcpzEK505 (DQ373065, SIVcpz65) and SIVcpzLB7 (DQ373064, SIVcpz64). Nucleotide coloring marks base pairs within pseudoknot stems P1 (red), P2 (blue), and TAR (dark green). Cyan color marks the TATA box sequence (CATATAA; [59]) that functions at the 5’terminus of HIV DNA as transcription promoter element. B Folding of the pseudoknot as predicted for the SIVcpz strains. SIVcpz RNA contains an additional helix between the pseudoknot and TAR wherein the TATA box is located (boxed). Representative examples from a deeper conservation analysis are shown

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Cell & Bioscience

ISSN: 2045-3701

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