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Fig. 2 | Cell & Bioscience

Fig. 2

From: Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma

Fig. 2

Treatment induced transcriptional changes in tumor cells. A UMAP embedding of myeloma cells colored by treatment time points (Pre and Post). B Bar plot of myeloma cell fraction in 9 matched pre and post samples. C Heat map of average expression of representative genes and corresponding pathways in pre and post-treatment samples. D Scores of UPR, metabolic-associated, stress-associated and immune reactive programs in each MM patient with matched pre and post samples. E Heat map of the area under the curve (AUC) scores of TF motifs estimated per cell by SCENIC. Shown are representative differentially activated motifs in nPCs (HD), myeloma cell pre and post-treated, respectively. Statistical analysis in D was performed by Wilcoxon test. HD, n = 3; pre, n = 9, post = 9; ns, not significant; **p < 0.01, ****p < 0.0001

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Cell & Bioscience

ISSN: 2045-3701

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