Fig. 5
From: RNA binding protein SAMD4: current knowledge and future perspectives
The main factors associated with the SAMD4 family members and their regulatory roles in cellular activities. A Interaction between SAMD4 and Akt leads to SAMD4 phosphorylation and affects the downstream mTORC1 signaling and metabolic regulation. B Hypermethylation of the CpG island of the SAMD4A gene promoter causes the silencing of circSAMD4A, which regulates tumour development. C Smaug recruits CCR4/POP2/NOT deadenylase complex to Hsp83 mRNA and causes target transcript destabilization and degradation. Smaug binds to nanos mRNA to inhibite the nanos protein translation and regulate the Drosophila embryogenesis