Fig. 3
From: RNA binding protein SAMD4: current knowledge and future perspectives
The domain compositions of SAMD4 protein family members and the structural characteristics of yeast Vts1p-SAM domain. A The domain compositions of SAMD4 protein members. Yeast Vts1p protein consists of 523 amino acids and one SAM domain. Drosophila Smaug protein consisits of 999 amino acids and four domains including SSR1, SSR2, SAM and PHAT domain. Human SAMD4A protein consists of 629 amino acids, while human SAMD4B protein consists of 694 amino acids. Both human SAMD4 proteins contain the common domains including SAM, SSR1, and SSR2 domains. B The structual characteristics of yeast Vts1p-SAM domain, which contains six α-helices, seven of these amino acids bind to SRE structure through hydrogen bonds. SAM, sterile alpha motif; SSR, Smaug similarity region. PHAT, pseudo heat analogous topology domain, which can increase the affinity of the SAM domain for SRE.