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Table 1 Measurement of liver and body weight, liver to body weight (LW/BW) ratio, liver steatosis, inflammation and total liver bile acid (BA) levels

From: Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity

Treatment (mice)

Liver weight, g

Body weight, g

LW/BW ratio, %

Steatosis, %

Inflammation, %

TBA, mM

WT CD

1.30 ± 0.08 (n = 6)

29.86 ± 1.15 (n = 6)

4.33 ± 0.16 (n = 6)

0.8 ± 0.84 (n = 6)

0.60 ± 0.89 (n = 6)

18.54 ± 3.19 (n = 9)

Sct−/− CD

1.77 ± 0.20 (n = 4)

38.34 ± 2.30 (n = 4)

4.57 ± 0.30 (n = 4)

1.33 ± 0.58 (n = 4)

1.00 ± 0.00 (n = 4)

16.23 ± 2.62 (n = 7)

WT EtOH

2.17 ± 0.21a (n = 4)

30.68 ± 1.73 (n = 4)

7.03 ± 0.33a (n = 4)

2.60 ± 0.55a (n = 5)

1.80 ± 0.45a (n = 5)

32.84 ± 7.02 (n = 10)

Sct−/− EtOH

1.24 ± 0.13b (n = 5)

29.37 ± 1.58 (n = 5)

4.19 ± 0.25b (n = 5)

1.25 ± 0.50b (n = 3)

1.00 ± 0.00b (n = 3)

15.01 ± 3.08b (n = 9)

  1. ap < 0.05 vs WT CD
  2. bp < 0.05 vs WT EtOH