From: Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity
Treatment (mice) | Liver weight, g | Body weight, g | LW/BW ratio, % | Steatosis, % | Inflammation, % | TBA, mM |
---|---|---|---|---|---|---|
WT CD | 1.30 ± 0.08 (n = 6) | 29.86 ± 1.15 (n = 6) | 4.33 ± 0.16 (n = 6) | 0.8 ± 0.84 (n = 6) | 0.60 ± 0.89 (n = 6) | 18.54 ± 3.19 (n = 9) |
Sct−/− CD | 1.77 ± 0.20 (n = 4) | 38.34 ± 2.30 (n = 4) | 4.57 ± 0.30 (n = 4) | 1.33 ± 0.58 (n = 4) | 1.00 ± 0.00 (n = 4) | 16.23 ± 2.62 (n = 7) |
WT EtOH | 2.17 ± 0.21a (n = 4) | 30.68 ± 1.73 (n = 4) | 7.03 ± 0.33a (n = 4) | 2.60 ± 0.55a (n = 5) | 1.80 ± 0.45a (n = 5) | 32.84 ± 7.02 (n = 10) |
Sct−/− EtOH | 1.24 ± 0.13b (n = 5) | 29.37 ± 1.58 (n = 5) | 4.19 ± 0.25b (n = 5) | 1.25 ± 0.50b (n = 3) | 1.00 ± 0.00b (n = 3) | 15.01 ± 3.08b (n = 9) |