Fig. 4

The Progressive Disease Index for the 871 metagenomic samples. 390 samples were control subjects (green), 67 samples were multiple polypoid adenomas with low-grade dysplasia (light blue), 167 samples were advanced adenomas (blue and dark blue), of which 106 were high-grade dysplastic adenoma (dark blue), 247 samples were colorectal cancer patients (orange, red and dark red), of which 128 were stage I/II colorectal cancer (red) and 87 were stage III/IV colorectal cancer (dark red). The Progressive Disease Index increases with the severity of the disease from the perspective of the trend, whose reference warning line was 75