Fig. 4

Pathway regulation and protein–protein interaction (PPI) visualization in organoids, neurons, and NPCs of schizophrenia patients versus controls regulated proteins. KEGG pathways found dysregulated by the differentially expressed proteins (DEP) from schizophrenia patients versus controls in A organoids, C NPCs, and E 21 DIV neurons are individually shown. Bars represent the number of DEPs found in a particular pathway and the color represents the enrichment adjusted p-value. The protein–protein interaction in B organoids connects proteins found regulated in mRNA splicing and metabolism of RNA. PPI of proteins regulated in D NPCs are related to translation, axon guidance, and oxidative phosphorylation. And PPI of proteins regulated in F neurons are part of cellular amino acid metabolic process and cytosolic tRNA aminoacylation. Circles in red indicate upregulation of proteins and green indicate downregulation of proteins. Circle size reflects the interaction degree of each protein. Analyses were performed using Metascape resources