Fig. 1
From: A synthetic pregnenolone analog promotes microtubule dynamics and neural development
Structures of major P5 metabolites. The structures of major P5 metabolites and the pathways leading to their formation are shown. The first enzymes in the pathways are also labeled. Pregnenolone (P5) can be converted into progesterone by HSD3B (3β-hydroxysteroid dehydrogenase), to pregnenolone sulfate by SULT (sulfotransferase), or to dehydroepiandrosterone by CYP17 (steroid 17α-monooxygenase) followed by other enzymes. Progesterone can be further metabolized into allopregnanolone, cortisol, and estradiol