Fig. 1
From: Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity
Transcriptic characterization of CD151 depletion in osteosarcoma and the clinical association between CD151 and sphingolipid metabolism. a Volcano plot of all genes from RNA-seq data in HOS-MNNG cells with CD151 WT compared with CD151 KO. The downregulated genes are shown in blue, and the upregulated genes are shown in red. b Geno Ontology (GO) enrichment analysis of differentially expressed genes between the WT and CD151 KO groups. GO terms comprising sphingolipid metabolic process and sphingolipid biosynthesis process are shown in red. c Gene Set Enrichment Analysis (GSEA) analysis identifies negatively enriched sphingolipid metabolism in HOS-MNNG cells after CD151 depletion. d Heatmap of the 16 genes contributing to sphingolipid metabolism GSEA enrichment plot. e Gene Set Enrichment Analysis (GSEA) analysis identifies positively enriched sphingolipid metabolism in patients samples with CD151 high expression. f The correlation between CD151 mRNA expression and sphingolipid metabolism related-genes in 103 patients’ tumor samples