Skip to main content
Fig. 5 | Cell & Bioscience

Fig. 5

From: PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders

Fig. 5

Sevoflurane exposure down-regulating PEX5R/Trip8b and HCN channels and activating microglia. A, Structure of PEX5R/Trip8b from UniProt Knowledgebase (https://www.uniprot.org/uniprot/Q925N3), which C and N terminus has a biochemical association with HCN channels. B, Sevoflurane down-regulated HCN1 mRNA (n = 4). C, Sevoflurane down-regulated HCN2 mRNA (n = 4). D, Sevoflurane down-regulated PEX5R mRNA (n = 4). E, Sevoflurane down-regulated HCN3 mRNA (n = 4). F, Sevoflurane down-regulated HCN4 mRNA (n = 4). G, Immunoblotting of iba1, PEX5R, and HCN2 in the hippocampus (n = 3). H, Sevoflurane up-regulated iba1 expression. I, Sevoflurane down-regulated PEX5R expression. J, Sevoflurane down-regulated HCN2 expression. K, L, Sevoflurane exposure activated microglia (n = 4). Arrows indicate microglia. Data are shown as mean ± SD. *P < 0.05 or **P < 0.01.

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us