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Fig. 8 | Cell & Bioscience

Fig. 8

From: IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis

Fig. 8

Cartoon illustration that depicts a model of IFITM3-mediated MET/ AKT/FOXO3/c-MYC cascade signaling pathway. Data presented in this study reveals a new signaling model in which IFITM3 associates with MET and AKT complex, leading to enhanced HGF/MET signaling as well as suppression of FOXO3, consequently resulting in upregulation of c-MYC to promote proliferation, metastasis, cancer stemness and chemoresistance of GC cells

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Cell & Bioscience

ISSN: 2045-3701

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